Now the son [Ishmael], born to the slave woman, was born simply of their natural relationship; but the son [Isaac], born to the free woman, was born in fulfillment of a [divine] promise.

Nicodemus said to Him, "How can a man be born [again] after he is [already] old? He cannot enter his mother's womb a second time and be born, can he?"

Whoever is born from human parents is a human being; and whoever is born from the Holy Spirit is a spiritual being.

A woman has pain when giving birth because her time has come. But when the child is born, she does not remember the intense suffering because she is so happy over the child being born into the world.

But, when [God's] timing fully arrived, He sent His Son, born to a woman [i.e., Mary], born during [the time when] the law [of Moses was still in effect],

But, just as it was then --- the son born in the ordinary way [i.e., Ishmael] persecuting the one born according to the Holy Spirit's [leading, i.e., Isaac] --- so it is now [i.e., Jews urging compliance with the requirements of the law of Moses persecuting those who refuse to return to dependance on that law for salvation. See 3:1-3].